Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis.

نویسندگان

  • Takahiro Ugai
  • Atsushi Minami
  • Ryuya Fujii
  • Mizuki Tanaka
  • Hiroki Oguri
  • Katsuya Gomi
  • Hideaki Oikawa
چکیده

A unique highly reducing polyketide synthase (HR-PKS) with a reductase domain was identified in a betaenone biosynthetic gene cluster. Successful heterologous expression and characterization of the HR-PKS and trans-acting enoyl reductase (ER) provide insights into the core structure formation with a decalin scaffold and allow reconstitution of the betaenone biosynthetic machinery.

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عنوان ژورنال:
  • Chemical communications

دوره 51 10  شماره 

صفحات  -

تاریخ انتشار 2015